General Info
| Host: | Rabbit |
| Applications: | DB/ELISA/IP/WB |
| Reactivity: | Bovine/Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PNPLA3 (150-200) is suitable for use in Dot Blot, ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.68-0.70 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:4, 000ELISA: 1:4, 000IP: 1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | PNPLA3 |
| Gene ID: | 80339 |
| Uniprot ID: | PLPL3_HUMAN |
| Immunogen Region: | 150-200 |
| Immunogen: | Synthetic peptide taken within amino acid region 150-200 on human Patatin-like phospholipase domain-containing protein 3. |
Description
| Function | Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides. In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety. However, the triacylglycerol hydrolase activity is controversial and may be very low. Possesses phospholipase A2 activity. |
| Protein Name | 1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3Acylglycerol TransacylaseAdiponutrinAdpnCalcium-Independent Phospholipase A2-EpsilonIpla2-EpsilonLysophosphatidic Acid AcyltransferasePatatin-Like Phospholipase Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-1482883 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinLipid Droplet |
| Alternative Antibody Names | Anti-1-Acylglycerol-3-Phosphate O-Acyltransferase Pnpla3 antibodyAnti-Acylglycerol Transacylase antibodyAnti-Adiponutrin antibodyAnti-Adpn antibodyAnti-Calcium-Independent Phospholipase A2-Epsilon antibodyAnti-Ipla2-Epsilon antibodyAnti-Lysophosphatidic Acid Acyltransferase antibodyAnti-Patatin-Like Phospholipase Domain-Containing Protein 3 antibodyAnti-PNPLA3 antibodyAnti-ADPN antibodyAnti-C22orf20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance