Anti-PDE3B antibody (1060-1110) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:500 ICC: 1:500 IF: 1:500 CFM: 1:500
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	Pde3b
Gene ID:	29516
Uniprot ID:	PDE3B_RAT
Immunogen Region:	1060-1110
Specificity:	Does not cross react with PDE4A variants nor with any other PDE famly members. This antibody will recognize PDE3B variants.
Immunogen:	Synthetic peptide taken within amino acid region 1060-1110 on human PDE3B protein.

Tissue Specificity	Abundant in adipose tissues.
Post Translational Modifications	Phosphorylation at Ser-279 mediates insulin-induced activation of PDE3B.
Function	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes.
Protein Name	Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b Cgi Pde Cyclic Gmp-Inhibited Phosphodiesterase B Cgi-Pde B Rcgipl
Database Links	Reactome: R-RNO-165160 Reactome: -RNO-418555
Cellular Localisation	Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b antibody Anti-Cgi Pde antibody Anti-Cyclic Gmp-Inhibited Phosphodiesterase B antibody Anti-Cgi-Pde B antibody Anti-Rcgipl antibody Anti-Pde3b antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance