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| Gene : | TNFRSF9 |
| Gene ID : | 3604 |
| Uniprot ID : | Q07011 |
| Alternative Name : | TNFRSF9, CD137, ILA |
| Immunogen Information : | Recombinant human CD137 ectodomain |
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
| Subcellular location: | Membrane |
| Tissue Specificity: | Expressed on the surface of activated T-cells. |
| BioGrid: | 109817. 13 interactions. |
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