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Stemolecule Forskolin

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Cat# 04-0025

Size : 10mg

Brand : ReproCELL


Stemolecule™ Forskolin

04-0025

Brand: Stemolecule

Forskolin is a natural product adenylate cyclase activator that increases cyclic AMP levels.

CAS Number: 66428-89-5
Alternate Name(s):
  • [(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl]acetate

Note: shown do not include shipping and handling charges.

Product Information

Stemolecule Forskolin is a natural compound produced by the Indian Coleus plant (Coleus forskohlii)1. It is used in several differentiation protocols for its ability to potentiate neuron differentiation2,3. Forskolin is able to stimulate adenylate cyclase activity and increases cyclic AMP4. Cyclic AMP is a signaling molecule and key regulator of critical enzymes in cellular processes5. For example, cAMP can bind to protein kinase A (PKA) regulatory subunit and activate PKA which acts as a negative regulator of the hedgehog signaling pathway6.

04-0025 Specifications Sheet

Safety Data Sheets:

Chen, T.C., Hinton, D.R., Zidovetzki, R., and Hofman, F.M. Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab Invest 78: 165-174 (1998).
  • Son, H., Kim, K.O., Kim, J.S., Chang, M.Y., Lee, S.H., and Lee, Y.S. Pairing of forskolin and KCl increases differentiation of immortalized hippocampal neurons in a CREB Serine 133 phosphorylation-dependent and extracellular-regulated protein kinase-independent manner. Neurosci Lett 308: 37-40 (2001).
  • Palmer, T.D., Takahashi, J., and Gage, F.H. The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci 8: 389-404 (1997).
  • Hedin, L., and Rosberg, S. Forskolin effects on the cAMP system and steroidogenesis in the immature rat ovary. Mol Cell Endocrinol 33: 69-80 (1983).
  • Sands, W.A., and Palmer, T.M. Regulating gene transcription in response to cyclic AMP elevation. Cell Signal 20: 460-466 (2008).
  • Hammerschmidt, M., Bitgood, M.J., and McMahon, A.P. Protein kinase A is a common negative regulator of hedgehog signaling in the vertebrate embryo. Genes Dev 10: 647-658 (1996).

    • Additional Publications

    • Pan T; Chen Y; Zhuang Y; Yang F; Xu Y; Tao J; You K; Wang N; Wu T; Lin X; Wu F; Liu Y; Wang G; Li L-X. Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts. Stem Cell Res Therapy 10:364 (2019).
    • Zhu S; Russ HA; Wang X; Zhang M; Ma T; Xu T; Tang S; Hebrok M; Deng S. Human pancreatic β-like cells converted from fibroblasts. Nature Commun 7:10080 (2016).
    • Saxena S; Ronn RE; Guibentif C; Moragheba R; Woods N-B. Cyclic AMP signaling through Epac axis modulates human hemogenic endothelium and enhances hematopoeitic cell generation. Stem Cell Rep doi:10.1016/j.stemcr.2016.03.006 (2016).
    • Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules. Stem Cells International 2016:4304916 (2016).